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KMID : 0191120180330430239
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Journal of Korean Medical Science
2018 Volume.33 No. 43 p.239 ~ p.239
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A Novel Fundus Image Reading Tool for Efficient Generation of a Multi-dimensional Categorical Image Database for Machine Learning Algorithm Training
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Park Sang-Jun
Shin Joo-Young
Kim Sang-Keun
Son Jae-Min
Jung Kyu-Hwan
Park Kyu-Hyung
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Abstract
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Background: We described a novel multi-step retinal fundus image reading system for providing high-quality large data for machine learning algorithms, and assessed the grader variability in the large-scale dataset generated with this system.
Methods: A 5-step retinal fundus image reading tool was developed that rates image quality, presence of abnormality, findings with location information, diagnoses, and clinical significance. Each image was evaluated by 3 different graders. Agreements among graders for each decision were evaluated.
Results: The 234,242 readings of 79,458 images were collected from 55 licensed ophthalmologists during 6 months. The 34,364 images were graded as abnormal by at-least one rater. Of these, all three raters agreed in 46.6% in abnormality, while 69.9% of the images were rated as abnormal by two or more raters. Agreement rate of at-least two raters on a certain finding was 26.7%?65.2%, and complete agreement rate of all-three raters was 5.7%?43.3%. As for diagnoses, agreement of at-least two raters was 35.6%?65.6%, and complete agreement rate was 11.0%?40.0%. Agreement of findings and diagnoses were higher when restricted to images with prior complete agreement on abnormality. Retinal/glaucoma specialists showed higher agreements on findings and diagnoses of their corresponding subspecialties.
Conclusion: This novel reading tool for retinal fundus images generated a large-scale dataset with high level of information, which can be utilized in future development of machine learning-based algorithms for automated identification of abnormal conditions and clinical decision supporting system. These results emphasize the importance of addressing grader variability in algorithm developments.
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KEYWORD
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Retina Fundus Image, Reading Tool, Grader, Machine Learning, Deep Learning
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